The Nature of Progression in Parkinson’s Disease: An Application of Non-Linear, Multivariate, Longitudinal Random Effects Modelling
Identifieur interne : 000C55 ( Main/Exploration ); précédent : 000C54; suivant : 000C56The Nature of Progression in Parkinson’s Disease: An Application of Non-Linear, Multivariate, Longitudinal Random Effects Modelling
Auteurs : Lisa Kuramoto [Canada] ; Jacquelyn Cragg [Canada] ; Ramachandiran Nandhagopal [Canada] ; Edwin Mak [Canada] ; Vesna Sossi [Canada] ; Raul De La Fuente-Fernández [Canada] ; A. Jon Stoessl [Canada] ; Michael Schulzer [Canada]Source :
- PLoS ONE [ 1932-6203 ] ; 2013.
English descriptors
- KwdEn :
- Age Factors, Age of Onset, Algorithms, Asymptomatic Diseases, Cross-Sectional Studies, Disease Progression, Humans, Longitudinal Studies, Models, Statistical, Parkinson Disease (diagnostic imaging), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Putamen (diagnostic imaging), Putamen (pathology), Putamen (physiopathology), Tomography, Emission-Computed.
- MESH :
- diagnostic imaging : Parkinson Disease, Putamen.
- pathology : Parkinson Disease, Putamen.
- physiopathology : Parkinson Disease, Putamen.
- Age Factors, Age of Onset, Algorithms, Asymptomatic Diseases, Cross-Sectional Studies, Disease Progression, Humans, Longitudinal Studies, Models, Statistical, Tomography, Emission-Computed.
Abstract
To date, statistical methods that take into account fully the non-linear, longitudinal and multivariate aspects of clinical data have not been applied to the study of progression in Parkinson’s disease (PD). In this paper, we demonstrate the usefulness of such methodology for studying the temporal and spatial aspects of the progression of PD. Extending this methodology further, we also explore the presymptomatic course of this disease.
Longitudinal Positron Emission Tomography (PET) measurements were collected on 78 PD patients, from 4 subregions on each side of the brain, using 3 different radiotracers. Non-linear, multivariate, longitudinal random effects modelling was applied to analyze and interpret these data.
The data showed a non-linear decline in PET measurements, which we modelled successfully by an exponential function depending on two patient-related covariates duration since symptom onset and age at symptom onset. We found that the degree of damage was significantly greater in the posterior putamen than in the anterior putamen throughout the disease. We also found that over the course of the illness, the difference between the less affected and more affected sides of the brain decreased in the anterior putamen. Younger patients had significantly poorer measurements than older patients at the time of symptom onset suggesting more effective compensatory mechanisms delaying the onset of symptoms. Cautious extrapolation showed that disease onset had occurred some 8 to 17 years prior to symptom onset.
Our model provides important biological insights into the pathogenesis of PD, as well as its preclinical aspects. Our methodology can be applied widely to study many other chronic progressive diseases.
Url:
DOI: 10.1371/journal.pone.0076595
PubMed: 24204641
PubMed Central: 3799835
Affiliations:
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type="wicri:Area/Main/Curation">000C55</idno><idno type="wicri:Area/Main/Exploration">000C55</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Nature of Progression in Parkinson’s Disease: An Application of Non-Linear, Multivariate, Longitudinal Random Effects Modelling</title><author><name sortKey="Kuramoto, Lisa" sort="Kuramoto, Lisa" uniqKey="Kuramoto L" first="Lisa" last="Kuramoto">Lisa Kuramoto</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centre for Clinical Epidemiology & Evaluation, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Clinical Epidemiology & Evaluation, Vancouver Coastal Health Research Institute, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Cragg, Jacquelyn" sort="Cragg, Jacquelyn" uniqKey="Cragg J" first="Jacquelyn" last="Cragg">Jacquelyn Cragg</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Nandhagopal, Ramachandiran" sort="Nandhagopal, Ramachandiran" uniqKey="Nandhagopal R" first="Ramachandiran" last="Nandhagopal">Ramachandiran Nandhagopal</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Mak, Edwin" sort="Mak, Edwin" uniqKey="Mak E" first="Edwin" last="Mak">Edwin Mak</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Department of Physics & Astronomy, The University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physics & Astronomy, The University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="De La Fuente Fernandez, Raul" sort="De La Fuente Fernandez, Raul" uniqKey="De La Fuente Fernandez R" first="Raul" last="De La Fuente-Fernández">Raul De La Fuente-Fernández</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Centre for Clinical Epidemiology & Evaluation, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Clinical Epidemiology & Evaluation, Vancouver Coastal Health Research Institute, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Pacific Parkinson’s Research Centre, The University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors</term><term>Age of Onset</term><term>Algorithms</term><term>Asymptomatic Diseases</term><term>Cross-Sectional Studies</term><term>Disease Progression</term><term>Humans</term><term>Longitudinal Studies</term><term>Models, Statistical</term><term>Parkinson Disease (diagnostic imaging)</term><term>Parkinson Disease (pathology)</term><term>Parkinson Disease (physiopathology)</term><term>Putamen (diagnostic imaging)</term><term>Putamen (pathology)</term><term>Putamen (physiopathology)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Putamen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Age of Onset</term><term>Algorithms</term><term>Asymptomatic Diseases</term><term>Cross-Sectional Studies</term><term>Disease Progression</term><term>Humans</term><term>Longitudinal Studies</term><term>Models, Statistical</term><term>Tomography, Emission-Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>To date, statistical methods that take into account fully the non-linear, longitudinal and multivariate aspects of clinical data have not been applied to the study of progression in Parkinson’s disease (PD). In this paper, we demonstrate the usefulness of such methodology for studying the temporal and spatial aspects of the progression of PD. Extending this methodology further, we also explore the presymptomatic course of this disease.</p></sec><sec><title>Methods</title><p>Longitudinal Positron Emission Tomography (PET) measurements were collected on 78 PD patients, from 4 subregions on each side of the brain, using 3 different radiotracers. Non-linear, multivariate, longitudinal random effects modelling was applied to analyze and interpret these data.</p></sec><sec><title>Results</title><p>The data showed a non-linear decline in PET measurements, which we modelled successfully by an exponential function depending on two patient-related covariates duration since symptom onset and age at symptom onset. We found that the degree of damage was significantly greater in the posterior putamen than in the anterior putamen throughout the disease. We also found that over the course of the illness, the difference between the less affected and more affected sides of the brain decreased in the anterior putamen. Younger patients had significantly poorer measurements than older patients at the time of symptom onset suggesting more effective compensatory mechanisms delaying the onset of symptoms. Cautious extrapolation showed that disease onset had occurred some 8 to 17 years prior to symptom onset.</p></sec><sec><title>Conclusions</title><p>Our model provides important biological insights into the pathogenesis of PD, as well as its preclinical aspects. Our methodology can be applied widely to study many other chronic progressive diseases.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hirtz, D" uniqKey="Hirtz D">D Hirtz</name></author><author><name sortKey="Thurman, Dj" uniqKey="Thurman D">DJ Thurman</name></author><author><name sortKey="Gwinn Hardy, K" uniqKey="Gwinn Hardy K">K Gwinn-Hardy</name></author><author><name sortKey="Mohamed, M" uniqKey="Mohamed M">M Mohamed</name></author><author><name sortKey="Chaudhuri, Ar" uniqKey="Chaudhuri A">AR Chaudhuri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scheife, Rt" uniqKey="Scheife R">RT Scheife</name></author><author><name sortKey="Schumock, Gt" uniqKey="Schumock G">GT Schumock</name></author><author><name sortKey="Burstein, A" uniqKey="Burstein A">A Burstein</name></author><author><name sortKey="Gottwald, Md" uniqKey="Gottwald M">MD Gottwald</name></author><author><name sortKey="Luer, Ms" uniqKey="Luer M">MS Luer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rubenstein, Lm" uniqKey="Rubenstein L">LM Rubenstein</name></author><author><name sortKey="Chrischilles, Ea" uniqKey="Chrischilles E">EA Chrischilles</name></author><author><name sortKey="Voelker, Md" uniqKey="Voelker M">MD Voelker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fahn, S" uniqKey="Fahn S">S Fahn</name></author><author><name sortKey="Oakes, D" uniqKey="Oakes D">D Oakes</name></author><author><name sortKey="Shoulson, I" uniqKey="Shoulson I">I Shoulson</name></author><author><name sortKey="Kieburtz, K" uniqKey="Kieburtz K">K Kieburtz</name></author><author><name sortKey="Rudolph, A" uniqKey="Rudolph A">A Rudolph</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Au, Wl" uniqKey="Au W">WL Au</name></author><author><name sortKey="Adams, Jr" uniqKey="Adams J">JR Adams</name></author><author><name sortKey="Troiano, Ar" uniqKey="Troiano A">AR Troiano</name></author><author><name sortKey="Stoessl, Aj" uniqKey="Stoessl A">AJ Stoessl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brooks, Dj" uniqKey="Brooks D">DJ Brooks</name></author><author><name sortKey="Frey, Ka" uniqKey="Frey K">KA Frey</name></author><author><name sortKey="Marek, Kl" uniqKey="Marek K">KL Marek</name></author><author><name sortKey="Oakes, D" uniqKey="Oakes D">D Oakes</name></author><author><name sortKey="Paty, D" uniqKey="Paty D">D Paty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Cs" uniqKey="Lee C">CS Lee</name></author><author><name sortKey="Samii, A" uniqKey="Samii A">A Samii</name></author><author><name sortKey="Sossi, V" uniqKey="Sossi V">V Sossi</name></author><author><name sortKey="Ruth, Tj" uniqKey="Ruth T">TJ Ruth</name></author><author><name sortKey="Schulzer, M" uniqKey="Schulzer M">M Schulzer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adams, Jr" uniqKey="Adams J">JR Adams</name></author><author><name sortKey="Van Netten, H" uniqKey="Van Netten H">H van Netten</name></author><author><name sortKey="Schulzer, M" uniqKey="Schulzer M">M Schulzer</name></author><author><name sortKey="Mak, E" uniqKey="Mak E">E Mak</name></author><author><name sortKey="Mckenzie, J" uniqKey="Mckenzie J">J Mckenzie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nandhagopal, R" uniqKey="Nandhagopal R">R Nandhagopal</name></author><author><name sortKey="Mckeown, M" uniqKey="Mckeown M">M McKeown</name></author><author><name sortKey="Stoessl, Aj" uniqKey="Stoessl A">AJ Stoessl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marshall, G" uniqKey="Marshall G">G Marshall</name></author><author><name sortKey="De La Cruz Mesia, R" uniqKey="De La Cruz Mesia R">R De la cruz Mesia</name></author><author><name sortKey="Baron, Ae" uniqKey="Baron A">AE Baron</name></author><author><name sortKey="Rutledge, Jh" uniqKey="Rutledge J">JH Rutledge</name></author><author><name sortKey="Zerbe, Go" uniqKey="Zerbe G">GO Zerbe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hilker, R" uniqKey="Hilker R">R Hilker</name></author><author><name sortKey="Schweitzer, K" uniqKey="Schweitzer K">K Schweitzer</name></author><author><name sortKey="Coburger, S" uniqKey="Coburger S">S Coburger</name></author><author><name sortKey="Ghaemi, M" uniqKey="Ghaemi M">M Ghaemi</name></author><author><name sortKey="Weisenbach, S" uniqKey="Weisenbach S">S Weisenbach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name></author><author><name sortKey="Tang, C" uniqKey="Tang C">C Tang</name></author><author><name sortKey="Feigin, A" uniqKey="Feigin A">A Feigin</name></author><author><name sortKey="Lesser, M" uniqKey="Lesser M">M Lesser</name></author><author><name sortKey="Ma, Y" uniqKey="Ma Y">Y Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bruck, A" uniqKey="Bruck A">A Brück</name></author><author><name sortKey="Aalto, S" uniqKey="Aalto S">S Aalto</name></author><author><name sortKey="Nurmi, E" uniqKey="Nurmi E">E Nurmi</name></author><author><name sortKey="Vahlberg, T" uniqKey="Vahlberg T">T Vahlberg</name></author><author><name sortKey="Bergman, J" uniqKey="Bergman J">J Bergman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Cs" uniqKey="Lee C">CS Lee</name></author><author><name sortKey="Schulzer, M" uniqKey="Schulzer M">M Schulzer</name></author><author><name sortKey="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R">R de la Fuente-Fernandez</name></author><author><name sortKey="Mak, E" uniqKey="Mak E">E Mak</name></author><author><name sortKey="Kuramoto, L" uniqKey="Kuramoto L">L Kuramoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwarz, J" uniqKey="Schwarz J">J Schwarz</name></author><author><name sortKey="Storch, A" uniqKey="Storch A">A Storch</name></author><author><name sortKey="Koch, W" uniqKey="Koch W">W Koch</name></author><author><name sortKey="Pogarell, O" uniqKey="Pogarell O">O Pogarell</name></author><author><name sortKey="Radau, Pe" uniqKey="Radau P">PE Radau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morrish, Pk" uniqKey="Morrish P">PK Morrish</name></author><author><name sortKey="Sawle, Gv" uniqKey="Sawle G">GV Sawle</name></author><author><name sortKey="Brooks, Dj" uniqKey="Brooks D">DJ Brooks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morrish, Pk" uniqKey="Morrish P">PK Morrish</name></author><author><name sortKey="Rakshi, Js" uniqKey="Rakshi J">JS Rakshi</name></author><author><name sortKey="Bailey, Dl" uniqKey="Bailey D">DL Bailey</name></author><author><name sortKey="Sawle, Gv" uniqKey="Sawle G">Gv Sawle</name></author><author><name sortKey="Brooks, Dj" uniqKey="Brooks D">DJ Brooks</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Laird, Nm" uniqKey="Laird N">NM Laird</name></author><author><name sortKey="Ware, Jh" uniqKey="Ware J">JH Ware</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindstrom, Mj" uniqKey="Lindstrom M">MJ Lindstrom</name></author><author><name sortKey="Bates, Dm" uniqKey="Bates D">DM Bates</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Spinks, Tj" uniqKey="Spinks T">TJ Spinks</name></author><author><name sortKey="Jones, T" uniqKey="Jones T">T Jones</name></author><author><name sortKey="Bailey, Dl" uniqKey="Bailey D">DL Bailey</name></author><author><name sortKey="Townsend, Dw" uniqKey="Townsend D">DW Townsend</name></author><author><name sortKey="Grootoonk, S" uniqKey="Grootoonk S">S Grootoonk</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Nandhagopal, R" uniqKey="Nandhagopal R">R Nandhagopal</name></author><author><name sortKey="Kuramoto, L" uniqKey="Kuramoto L">L Kuramoto</name></author><author><name sortKey="Schulzer, M" uniqKey="Schulzer M">M Schulzer</name></author><author><name sortKey="Mak, E" uniqKey="Mak E">E Mak</name></author><author><name sortKey="Cragg, J" uniqKey="Cragg J">J Cragg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R">R de la Fuente-Fernandez</name></author><author><name sortKey="Schulzer, M" uniqKey="Schulzer M">M Schulzer</name></author><author><name sortKey="Kuramoto, L" uniqKey="Kuramoto L">L Kuramoto</name></author><author><name sortKey="Cragg, J" uniqKey="Cragg J">J Cragg</name></author><author><name sortKey="Nandhagopal, R" uniqKey="Nandhagopal R">R Nandhagopal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nandhagopal, R" uniqKey="Nandhagopal R">R Nandhagopal</name></author><author><name sortKey="Kuramoto, L" uniqKey="Kuramoto L">L Kuramoto</name></author><author><name sortKey="Schulzer, M" uniqKey="Schulzer M">M Schulzer</name></author><author><name sortKey="Mak, E" uniqKey="Mak E">E Mak</name></author><author><name sortKey="Cragg, J" uniqKey="Cragg J">J Cragg</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Kuramoto, Lisa" sort="Kuramoto, Lisa" uniqKey="Kuramoto L" first="Lisa" last="Kuramoto">Lisa Kuramoto</name></noRegion><name sortKey="Cragg, Jacquelyn" sort="Cragg, Jacquelyn" uniqKey="Cragg J" first="Jacquelyn" last="Cragg">Jacquelyn Cragg</name><name sortKey="De La Fuente Fernandez, Raul" sort="De La Fuente Fernandez, Raul" uniqKey="De La Fuente Fernandez R" first="Raul" last="De La Fuente-Fernández">Raul De La Fuente-Fernández</name><name sortKey="Mak, Edwin" sort="Mak, Edwin" uniqKey="Mak E" first="Edwin" last="Mak">Edwin Mak</name><name sortKey="Nandhagopal, Ramachandiran" sort="Nandhagopal, Ramachandiran" uniqKey="Nandhagopal R" first="Ramachandiran" last="Nandhagopal">Ramachandiran Nandhagopal</name><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><name sortKey="Schulzer, Michael" sort="Schulzer, Michael" uniqKey="Schulzer M" first="Michael" last="Schulzer">Michael Schulzer</name><name sortKey="Sossi, Vesna" sort="Sossi, Vesna" uniqKey="Sossi V" first="Vesna" last="Sossi">Vesna Sossi</name><name sortKey="Stoessl, A Jon" sort="Stoessl, A Jon" uniqKey="Stoessl A" first="A. Jon" last="Stoessl">A. Jon Stoessl</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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